Rotten timber beams and Hightech: Half timbered house from that 18. Century is equipped with clean-room technology

300 years old advice pharmacy in Uslar production extends from cytostatic drug who with monument-protected half timbered houses of dusty timber beams and ailing floors thinks immediately, in this case will be astonished: The new manufacturing plant of the advice pharmacy in Uslar for the cytostatic drug preparation for the treatment from cancer is in a building from that 18. Century, yet all editions for the quality assurance of the production flows had to be fulfilled.� More than 200 years an old house with most modern clean-room technology to equip, many surprises for the companies meal brought to pure area realization kg and the Nerling system area GmbH with itself. Loam plaster, straw and bars in the most unfavorable places made partly a planning of the pure areas from section necessary to section. And because there was no wall rectangular and the areas was differently high, also walls and covers had to be particularly made. � before planning, in this house is simple nothing straight was conscious to us already �, says January K�rbis, project manager of the Nerling system area GmbH. Nevertheless the planners of the new manufacturing plant of the advice pharmacy did not want a modern new building, but a continuation of the symbiosis from tradition and modern trend. � after our laboratory pushed Hermann Rohlfs, director/conductor of the advice pharmacy Uslar for the production of individual cytostatic drug preparations in the advice pharmacy to its borders, decided we into a new manufacturing plant to invest �, reports. Already into the 1920er years the advice pharmacy was operated as � factory for pharmaceutical preparations �. Therefore the new manufacture areas in a monument-protected half timbered house on the opposite roadside of the pharmacy were established. A characteristic of this factory: Interested has the possibility by windowpanes production in the pure area to pursue. Loam plaster, inclined walls and different H�henniveausDie planning of the pure areas took place first by routine. � fortunately the monument protection of the building referred only to the external opinion and/or the front �, thus Wolfgang meal of the meals pure area realization kg. � pure optically looked those so far as specialist shop for radio and television used area quite properly. � within the range of the manufacture areas however the entire ground range had to be ausgeschachtet, in order to receive place for the ventilation ducts due to the small room height of 2.40 meters. Afterwards a light room height of 2.80 meters was to the pure space technicians at the disposal, and it had again to be planned. The further the building progressed, the more challenges waited for the experts. � partial had to be revised the plans from section to section �, explain meal. Suddenly old loam plaster and straw emerged and timber beams stood in the way, where they were not to be located so far. � with a house from that 18. Century with numerous changes theory and practice are even two different pair of shoes. � so gave it practically no right-angled walls, why the company Nerling, who was assigned the supply of walls, covers and material locks, had to measure all walls in every detail. Afterwards on the computer fictitious parallels were drawn and computed by trigonometric function the actual inclination of the walls. � also the covers had different elevator levels �, say K�rbis. With staircases had to be paid attention therefore to the minimum passage height. Cover leaps made of wood were abgekoffert and also truss had to be partly disguised. Actively ventilated material locks hold contamination small those for requirements by sterile laboratories are fixed in numerous regulations. For the security of drugs the GMP (Good Manufacturing Practice) must be kept the PIC (Pharmaceutical Inspection Convention) also the defaults of the WHO and the drug law apart from the DIN ISO 14644 and. Among other things changes of air, space target temperature and the cleaning barness of the areas very rigid are specified. � the humidity does not play a substantial role in this case, then meal could be done without and dehumidifying �, explains. Nevertheless one made sure when planning of the pure areas that the humidity values remain by the interpretation and of the exhaust air generally frameworks. That is, also with particularly cold or stifling climatic conditions it will come only very rarely to problems with the space humidity. In order to be able to transport the necessary materials of the camp into a Vorbereitungsraum and finally into the manufacture area, material locks were furnished. � these material locks are ventilated actively, thus the contamination �, so as small as possible held K�rbis. �In June the enterprise at the two work benches was taken up in the manufacture areas already, the production capacity of the cytostatic drug preparation increased thereby the quadruple. � the generous cut of the new manufacturing plant makes an uncomplicated and fast extension for us possible �, thus Rohlfs. Thus a market-bound flexibility is given and production can depending upon need be further increased.�

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