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All publications for the rubric Science

Radiopharmaceuticals are used when chemotherapy, surgery, or radiation have proven ineffective against a tumor. Microphysiological systems emulate the body's microenvironment and provide an easy-to-use platform for cultivating 3D tumor models. © Amac Garbe/Fraunhofer IWS A project team from HZDR and Fraunhofer IWS is researching how to use so-called microphysiological systems to reduce animal testing, which is currently necessary before human application. © Amac Garbe/Fraunhofer IWS First tests with the multi-organ chips already showed positive results. The binding of known substances to the tumor spheroids already worked. It is planned to further extend the microphysiological system by adding a kidney model and a liver organoid. © Amac Garbe/Fraunhofer IWS Binding of [68Ga]Ga-C225 (2 nM) in MPS modules on A431 (A) and MDA-MB435S (C); (B) shows the nonspecific binding on A431, (D) on MDA-MB435S (0.8 μM C225); below: diagrams of saturation assays on A431 monolayer in MPS chips with [64Cu]Cu-C225 (E) and [68Ga]Ga-C225 (F) (black, gray, red symbols: total, nonspecific, specific binding). © HZDR/Fraunhofer IWS
  • Science

Two Dresden Research Institutes want to Reduce the Number of Animal Experiments in Radiopharmaceutical Research with a New Idea

Radioactive Substances Fight Cancer in the Mini-lab

Radioactivity can save lives. When neither chemotherapy or surgery nor radiation from the outside help against a tumor, modern medicine uses so-called radiopharmaceuticals. These radioactive drugs not only detect cancer cells, they also enable targeted radiation from the inside to destroy the tumor…

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