Working in cleanrooms (Grades A–D), particularly aseptic manipulations, is a prerequisite for successful pharmaceutical manufacturing. Employees should be well prepared and trained for the special working conditions and processes in the cleanroom. Learn in the cleanroom which requirements of the regulations (EU GMP Annex 1, ATMP Guideline) are relevant and practise the critical processes in practice. For example, how to prepare properly for the cleanroom, how to enter the cleanroom (e.g. gowning), how to move your materials through the different grades, which rules generally apply to behaviour in the cleanroom, which contamination risks exist and how to monitor them. And, of course, how to work aseptically yourself in the highest cleanroom grade, Grade A.