B Medical Systems emphasizes the importance of storage at extremely low temperatures for the preservation of cancer biomarkers

Symbolic image (Source: B Medical Systems)

Ultra-low temperature freezer U700

Ultra-low temperature freezer U700 open door

The use of tumor markers for diagnosis, long-term prognosis assessment, and the selection of appropriate cancer therapies has revolutionized the field of molecular diagnostics. However, the integrity of these biomarkers during processing and storage is crucial to ensure accurate and reliable results. In a new white paper, B Medical Systems highlights the paramount importance of storage at extremely low temperatures to maintain the stability of key cancer biomarkers in fluids, cells, and tissue samples.

Through research on the preservation of tissue nucleic acids and proteins, as well as circulating tumor markers, B Medical Systems provides valuable insights for the medical and scientific community. Luc Provost, the company's CEO, emphasizes how important it is to preserve the stability and quality of samples in cancer research. He explains: “In cancer research, storing samples in ultra-low freezers is critical. Many biomarkers require stability and quality, as demonstrated by various studies in our white paper. When bioprobes are primarily used for DNA and protein analyses, long-term storage at temperatures between -70°C or -80°C can be effective. To achieve this level of temperature uniformity and sample security, investments in cold chain infrastructure may be necessary depending on the initial situation.”

Nucleic acids and proteins from tissues play an important role in the investigation of cancer biomarkers. Storing tissue samples at or below -70°C or -80°C ensures high-quality nucleic acids and preserves proteome profiles, enabling accurate analysis of DNA, RNA, and proteins.[1]

Circulating tumor markers, such as circulating free DNA (cfDNA), are also important indicators for cancer diagnosis. Preserving plasma samples at very cold temperatures and avoiding freeze-thaw cycles enable reliable analysis of these markers. Proper storage at ultra-low temperatures guarantees the stability of nucleic acids and other tumor indicators.[2]

As a globally active manufacturer and provider of reliable ultra-low temperature equipment, B Medical Systems recognizes the importance of maintaining the stability and quality of biomarkers in cancer research. The solutions equipped with high-quality technologies from B Medical Systems offer precise temperature control, uniformity, and increased sample security. The company's strong focus on regulatory compliance ensures the production of high-quality medical devices.

Ensuring a state-of-the-art cold chain infrastructure is essential for researchers and medical professionals to maintain the integrity and reliability of cancer biomarkers and ultimately advance oncology.

The free white paper can be downloaded here: https://www.bmedicalsystems.com/en/white-papers/stability-of-cancer-biomarkers-under-ultra-low-temperature-storage/

[1] Tang, W., Hu, Z., Muallem, H., & Gulley, M. L. (2012). Quality assurance of RNA expression profiling in clinical laboratories. The Journal of molecular diagnostics: JMD, 14(1), 1–11. https://doi.org/10.1016/j.jmoldx.2011.09.003
2 Grölz, D., Hauch, S., Schlumpberger, M., Guenther, K., Voss, T., Sprenger-Haussels, M., & Oelmüller, U. (2018). Liquid Biopsy Preservation Solutions for Standardized Preanalytical Workflows-Venous Whole Blood and Plasma. Current pathobiology reports, 6(4), 275–286. https://doi.org/10.1007/s40139-018-0180-z